Noah Britton, Ethan Finlan, Jack Hanke and New Michael Ingemi met at a camp for kids who are on the autism spectrum. After the meeting, they formed the sketch-comedy troupe Asperger's Are Us. Since 2010, the foursome have performed more than 100 shows in nine countries. On their first cross-country tour, crammed into a relic of an RV, HBO documents a trip that tests the guys' understanding of friendship and comedy and challenges them to leave their comfort zones. Along the way, they share their unique perspectives on life as an "Aspie" and the community they've found in performing together as a comedy troupe.