Part of Cartoon Network's Adult Swim block, "12 oz. Mouse" follows the animated adventures of Mouse Fitzgerald, an unapologetic drunken mouse with a background in espionage and a complete lack of memory. Fitz, as he is called, performs odd jobs, often with the help of his sidekick, a chinchilla named Skillet, as he tries to regain his memory.
Industry Man and his Clock persona are destroyed.
As the Castellica saves Mouse and team, Rooster escapes the clutches of Industry Man.
Industry Man interrogates Rooster on the location of the missing Box of Worlds; Peanut Cop dies while freeing Mouse, Aria and Eyeball from the laser cage; the Castellica gets its orders from Melissa to save Mouse.
Mouse realizes the Box of Worlds has been stolen and is now unstable just as Peanut Cop and Golden Joe come to their rescue; Rooster meets with Sirus and formulates a plan to take down Shyd Industries; Wilx finds his way into Outer Earth.
Sirus, the Architect for the Box of Worlds, breaks ranks with Clock; Aria and Eyeball use a serum to kick-start Mouse's memory, and he remembers working with them and helping to create the Box of Worlds; Wilx traps them in a laser cage and escapes.
Rooster escapes Spider from the World of Muck and finds himself in a desert with a well-armed Kid camping out; Peanut Cop and Golden Joe break out of prison on jet skis; Aria starts to realize that Professor Wilx is working for Shyd Industries.
Eyeball reunites with Mouse on Lotharganin; Manwoman, in the Outer Earth, is interrogated by Peanut Cop because she has the Box of Worlds in her possession created by Shyd Industries.
A Schooner breaks through the defenses of Lotharganin, and all clues point to Professor Wilx and his underlying connection to Shyd Industries.
While Shark is being reconstructed into an abomination, Golden Joe and Peanut try to figure a way out of their jail cell; Aria tries to jog Mouse's memory while Wilx is convinced that Mouse could be the Core to the whole experiment.
Mouse finds himself without memory and in a new world called Lotharganin, where he meets Aria and Professor Wilx, two top scientists from the Outer Earth who worked with Shyd Industries.
The cast of "12 oz. Mouse" answers all the questions viewers have been dying to ask.